1H-2-Benzazepin-1-one, 2,3,4,5-tetrahydro-8-methoxy-

1H-2-Benzazepin-1-one, 2,3,4,5-tetrahydro-8-methoxy- - Names and Identifiers

Name	8-Methoxy-2,3,4,5-tetrahydrobenzo[c]azepin-1-one
Synonyms	4-Methoxy-2,3,5,6-tetrafluorobenzoicacid 8-methoxy-2,3,4,5-tetrahydro-2-benzazepin-1-one 8-Methoxy-2,3,4,5-tetrahydrobenzo[c]azepin-1-one 8-METHOXY-2,3,4,5-TETRAHYDRO-BENZO[C]AZEPIN-1-ONE 8-Methoxy-2,3,4,5-tetrahydro-1H-2-benzazepin-1-one 8-methoxy-2,3,4,5-tetrahydro-1H-2-benzazepin-1-one 1H-2-Benzazepin-1-one, 2,3,4,5-tetrahydro-8-methoxy- 8-methoxy-2,3,4,5-tetrahydro-1H-benzo[c]azepin-1-one
CAS	22246-71-5
EINECS	604-604-1
InChI	InChI=1/C11H13NO2/c1-14-9-5-4-8-3-2-6-12-11(13)10(8)7-9/h4-5,7H,2-3,6H2,1H3,(H,12,13)

1H-2-Benzazepin-1-one, 2,3,4,5-tetrahydro-8-methoxy- - Physico-chemical Properties

Molecular Formula	C11H13NO2
Molar Mass	191.23
Density	1.121g/cm³
Boling Point	440.2°C at 760 mmHg
Flash Point	220°C
Vapor Presure	6.02E-08mmHg at 25°C
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.536

1H-2-Benzazepin-1-one, 2,3,4,5-tetrahydro-8-methoxy- - Introduction

8-Methoxy-2,3,4,5-tetrahydrobenzo[c]azepin-1-one(8-Methoxy-2,3,4,5-tetrahydrobenzo[c]azepin-1-one) is an organic compound. The following is a description of its nature, use, formulation and safety information:

Nature:
-Appearance: White to light yellow solid
-molecular formula: C13H15NO2
-Molecular weight: 217.26g/mol
-Melting Point: 102-103 ℃
-Boiling point: 344-345 ℃
-Solubility: Soluble in organic solvents, such as alcohol, ether, etc.

Use:
- 8-Methoxy-2,3,4,5-tetrahydrobenzo[c]azepin-1-one is a drug intermediate widely used in the field of drug synthesis.
-It can be used to synthesize biologically active compounds, such as antipsychotic and anxiolytic drugs.

Method:
- 8-Methoxy-2,3,4,5-tetrahydrobenzo[c]azepin-1-one can be synthesized by the reaction of methyl p-benzoylpropionate with benzenesulfonic acid.
-First, methyl benzoylpropionate and benzenesulfonic acid are subjected to a tungsten trioxide-catalyzed transesterification reaction under alkaline conditions to obtain benzyl benzoylpropionate.
-Next, the target product 8-Methoxy-2,3,4,5-tetrahydrobenzo[c]azepin-1-one was obtained by substituting the amine under the condition of adding methanol to dimethyl carbonate.

Safety Information:
- 8-Methoxy-2,3,4,5-tetrahydrobenzo[c]azepin-1-one should be used with caution, only under laboratory conditions, and with appropriate personal protective measures.
-When handling this compound, it is recommended to wear protective gloves, goggles and laboratory coats to avoid contact with skin and eyes.
-Avoid inhaling the dust or gas of the compound, and operate in a well-ventilated place.
-If ingested or touched by mistake, consult a doctor immediately and show the relevant safety data sheet to the doctor.

Last Update：2024-04-09 21:01:54